pentobarbital will reduce the extent or result of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration. Solid or average CYP3A inducers might lower cobimetinib systemic publicity by >eighty% and decrease its efficacy.
pentobarbital decreases levels of ponatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Keep away from Except if the coadministration outweighs the achievable chance of ponatinib underexposure; monitor for indications of minimized efficacy.
pentobarbital will reduce the level or result of bedaquiline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Stay away from coadministration of bedaquiline with powerful CYP3A4 inducers on account of likely for decreased therapeutic effect
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pentobarbital will decrease the level or effect of read more carvedilol by impacting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Observe.
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Tiny analgesia is conferred by barbiturates; their use inside the existence of discomfort may possibly bring about excitation.
Estradiol, estrone, progesterone and other steroidal hormones: Pretreatment with or concurrent administration of phenobarbital could lower the result of estradiol by escalating its metabolism.
pentobarbital will lower the extent or impact of isavuconazonium sulfate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated.